Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci
Abstract
A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Disciplines
Biology
DOI
10.1128/AEM.01831-08
Full Publication Date
February 2009
Publisher
American Society for Microbiology
Resource Type
journal article
Access Rights
open access
License Condition
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Horgan, Marianne; O'Flynn, Gary; Garry, Jennifer; Cooney, Jakki; Coffey, Aidan; Fitzgerald, Gerald F.; Paul Ross, R.; and McAuliffe, Olivia, "Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci" (2009). Department of Biological Sciences Publications [online].
Available at: https://doi.org/10.1128/AEM.01831-08
Publication Details
Applied and Environmental Microbiology