The recombinant phage lysin LysK has a broad spectrum of lytic activity against clinically relevant staphylococci, including methicillin-resistant Staphylococcus aureus
Abstract
This study concerns the cloning, characterization, and expression of the lysin (LysK) from staphylococcal phage K in Lactococcus lactis. Lactococcal lysates containing recombinant LysK were found to inhibit a range of different species of staphylococci isolated from bovine and human infection sources, including methicillin-resistant Staphylococcus aureus. LysK thus has potential as an antimicrobial for applications in the prevention and/or treatment of infections caused by staphylococci. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Disciplines
Biology
DOI
10.1128/JB.187.20.7161-7164.2005
Full Publication Date
October 2005
Publisher
American Society for Microbiology
Resource Type
journal article
Access Rights
restricted access
Recommended Citation
O'Flaherty, S.; Coffey, Aidan; Meaney, W.; Fitzgerald, G. F.; and Ross, R. Paul, "The recombinant phage lysin LysK has a broad spectrum of lytic activity against clinically relevant staphylococci, including methicillin-resistant Staphylococcus aureus" (2005). Department of Biological Sciences Publications [online].
Available at: https://doi.org/10.1128/JB.187.20.7161-7164.2005
Publication Details
Journal of Bacteriology