Abstract
In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than the standards isoniazid or fluconazole. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed.
Disciplines
Biology
DOI
10.3390/molecules15010288
Full Publication Date
January 2010
Publisher
MDPI
Funder Name 1
Irish Department of Education and Science
Award Number 1
1-06/CR08
Resource Type
journal article
Access Rights
open access
License Condition
This work is licensed under a Creative Commons Attribution 4.0 International License.
Alternative Identifier
https://www.mdpi.com/1420-3049/15/1/288/htm
Recommended Citation
Musiol, R. et al., 2010. Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines. Molecules, 15(1), pp.288–304. Available at: http://dx.doi.org/10.3390/molecules15010288.
Publication Details
Molecules
Copyright © 2010 Musiol, T. et al.
This study was supported by the Polish Ministry of Science N405 178735, by the Ministry of Education of the Czech Republic MSM 6215712403 and by the Irish Department of Education and Science TSR Strand1-06/CR08 and by Sanofi-Aventis Pharma Slovakia.