Abstract

Citrate toxicity from platelet apheresis donation has been extensively reported. Effects include symptomatic adverse reactions, silent prolongation of QTc interval on an electrocardiogram and long-term bone effects. While haemostatic impairment is not of concern in healthy plateletpheresis donors, these donors receive doses of citrate during the procedures that induce significant in vivo anticoagulation. We wished to measure the effects this process has on other markers of haemostatic homeostasis, and, in particular, on protein C activity levels. Protein C binds to its activation complex through divalent cation bridges, and is, therefore, susceptible to inactivation by citrate: an effect on protein C turnover from prolonged citrate infusion could be anticipated.

Disciplines

Biology | Life Sciences | Medical Sciences

DOI

10.2450/2016.0317-15

Full Publication Date

January 2016

Publication Details

Blood Transfusion 2016; 14: 513-4. © 2016 SIMTI Servizi Srl.

Publisher

SIMTI Servizi Srl

Resource Type

letter to the editor

Access Rights

restricted access

Alternative Identifier

https://www.bloodtransfusion.it/public/pre2018archives/2016/BloodTransfus2016_Vol14_Issue_6_513-514_317-15.pdf

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