Unravelling the Genetic Basis of Schizophrenia

Authors

Clara Casey, Department of Biological Sciences, Munster Technological University, Bishopstown, Cork, Ireland; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States;
John F. Fullard, Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Roy D. Sleator, Department of Biological Sciences, Munster Technological University, Bishopstown, Cork, IrelandFollow

ORCID

https://orcid.org/0009-0002-9430-3557

Abstract

Neuronal development is a highly regulated mechanism that is central to organismal function in animals. In humans, disruptions to this process can lead to a range of neurodevelopmental phenotypes, including Schizophrenia (SCZ). SCZ has a significant genetic component, whereby an individual with an SCZ affected family member is eight times more likely to develop the disease than someone with no family history of SCZ. By examining a combination of genomic, transcriptomic and epigenomic datasets, large-scale ‘omics’ studies aim to delineate the relationship between genetic variation and abnormal cellular activity in the SCZ brain. Herein, we provide a brief overview of some of the key omics methods currently being used in SCZ research, including RNA-seq, the assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and high-throughput chromosome conformation capture (3C) approaches (e.g., Hi-C), as well as single-cell/nuclei iterations of these methods. We also discuss how these techniques are being employed to further our understanding of the genetic basis of SCZ, and to identify associated molecular pathways, biomarkers, and candidate drug targets.

Disciplines

Biology | Genetics and Genomics | Life Sciences

DOI

10.1016/j.gene.2024.148198

Full Publication Date

April 2024

Publication Details

Gene, vol. 902. ©2024 The Author(s).

Publisher

Elsevier

Resource Type

journal article

Access Rights

open access

License Condition

This work is licensed under a Creative Commons Attribution 4.0 International License.

Alternative Identifier

https://www.sciencedirect.com/science/article/pii/S0378111924000799?via%3Dihub

Recommended Citation

Clara Casey, John F. Fullard, Roy D. Sleator, Unravelling the genetic basis of Schizophrenia, Gene, Volume 902, 2024, https://doi.org/10.1016/j.gene.2024.148198.