Abstract
An overwhelming array of structural variants has evolved from a comparatively small number of protein structural domains; which has in turn facilitated an expanse of functional derivatives. Herein, I review the primary mechanisms which have contributed to the vastness of our existing, and expanding, protein repertoires. Protein function prediction strategies, both sequence and structure based, are also discussed and their associated strengths and weaknesses assessed.
Disciplines
Biochemistry | Biochemistry, Biophysics, and Structural Biology | Biology | Genetics and Genomics
DOI
10.4161/bbug.18303
Full Publication Date
March 2012
Publisher
Taylor & Francis
Funder Name 1
ESCMID Society
Resource Type
review
Access Rights
restricted access
Open Access Route
Bronze Open Access
Alternative Identifier
https://www.tandfonline.com/doi/full/10.4161/bbug.18304
Recommended Citation
Sleator, R.D. (2012). Proteins. Bioengineered, [online] 3(2), pp.80–85. Available at: https://www.tandfonline.com/doi/full/10.4161/bbug.18303
Included in
Biochemistry Commons, Biology Commons, Genetics and Genomics Commons
Publication Details
Bioengineered
Originally published by Landes Sciences, which was acquired by Taylor & Francis in June 2014