Marine and Plant Bio-extracts for Bovine Udder Health in Mastitis (MAPBIO-MILK)

ORCID

https://orcid.org/0009-0004-8824-8189

Department

Department of Biological and Pharmaceutical Sciences

Year of Study

1

Full-time or Part-time Study

Full-time

Level

Postgraduate

Presentation Type

Poster

Supervisor

Dr Joanna B Tierney

Supervisor

Dr Bridget Breen

Supervisor

Dr Ashley Sullivan , Dr Venkata Vampsi B Yallapragada

Abstract

Background

Bovine mastitis is an infection of the mammary gland characterised by an increase in somatic cell count and inflammation of the udder. It significantly reduces milk quality and yield causing devastating financial loss within Irish dairy farms. The objective of this research is to create an antimicrobial and anti-inflammatory topical product from marine and plant bio-extracts and a novel biosensor will be modified to enable timely detection of mastitis.

Aims

  • Establish a 3D cell culture bovine mammary epithelial cell model to evaluate bio-extracts with antagonistic effects against mastitis-causing bacteria,
  • Evaluate bio-extracts capacity to influence bacterial infection in-vitro by assessing the ability of pathogenic bacteria to infect host cells,
  • Evaluate the bio-extracts ability to modulate mammary immune and antioxidant responses by examining inflammatory cytokine induction,
  • Determine the role of bio-extracts in protecting mammary health during bacterial challenge by analysing mammary epithelial cell barrier integrity and wound healing

Future Research Plans

  • Establish an in-vitro bovine mammary cell model
  • Select suitable bio-extracts and assess them via cytotoxicity testing
  • Select the appropriate mastitis-causing bacteria for in-vitro studies
  • Modify a novel biosensor for field trial analysis

Proposed Significance to the Field of Research

Preventing mastitis and enabling timely detection is vital to increase animal welfare and minimise financial loss. Currently, bovine mastitis is one of the major causes of financial loss on Irish dairy farms, costing €60/cow/year (Teagasc,2021). The modification of a novel biosensor to timely detect somatic cell count will allow immediate treatment preventing the disease progressing to an acute infection. Creating a natural topical product will help minimise antimicrobial use and antimicrobial resistance.

Keywords:

mastitis, bio-extracts, biosensor, dairy, inflammation, cell culture

Start Date

16-6-2025 11:00 AM

End Date

16-6-2025 12:00 PM

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Jun 16th, 11:00 AM Jun 16th, 12:00 PM

Marine and Plant Bio-extracts for Bovine Udder Health in Mastitis (MAPBIO-MILK)

Background

Bovine mastitis is an infection of the mammary gland characterised by an increase in somatic cell count and inflammation of the udder. It significantly reduces milk quality and yield causing devastating financial loss within Irish dairy farms. The objective of this research is to create an antimicrobial and anti-inflammatory topical product from marine and plant bio-extracts and a novel biosensor will be modified to enable timely detection of mastitis.

Aims

  • Establish a 3D cell culture bovine mammary epithelial cell model to evaluate bio-extracts with antagonistic effects against mastitis-causing bacteria,
  • Evaluate bio-extracts capacity to influence bacterial infection in-vitro by assessing the ability of pathogenic bacteria to infect host cells,
  • Evaluate the bio-extracts ability to modulate mammary immune and antioxidant responses by examining inflammatory cytokine induction,
  • Determine the role of bio-extracts in protecting mammary health during bacterial challenge by analysing mammary epithelial cell barrier integrity and wound healing

Future Research Plans

  • Establish an in-vitro bovine mammary cell model
  • Select suitable bio-extracts and assess them via cytotoxicity testing
  • Select the appropriate mastitis-causing bacteria for in-vitro studies
  • Modify a novel biosensor for field trial analysis

Proposed Significance to the Field of Research

Preventing mastitis and enabling timely detection is vital to increase animal welfare and minimise financial loss. Currently, bovine mastitis is one of the major causes of financial loss on Irish dairy farms, costing €60/cow/year (Teagasc,2021). The modification of a novel biosensor to timely detect somatic cell count will allow immediate treatment preventing the disease progressing to an acute infection. Creating a natural topical product will help minimise antimicrobial use and antimicrobial resistance.