Abstract
In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The compounds were analyzed by RP-HPLC to determine lipophilicity. They were tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than that of the standard isoniazid. It was found that the electronic properties of the R substituent, and not the total lipophilicity of the compound, were decisive for the photosynthesis-inhibiting activity of tested compounds.
Disciplines
Biology
DOI
10.3390/molecules14104246
Full Publication Date
October 2009
Publisher
MDPI
Funder Name 1
Irish Department of Education and Science
Award Number 1
1-06/CR08
Resource Type
journal article
Access Rights
open access
License Condition
This work is licensed under a Creative Commons Attribution 4.0 International License.
Alternative Identifier
https://www.mdpi.com/1420-3049/14/10/4246/htm
Recommended Citation
Jampilek, J. et al., 2009. Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues. Molecules, 14(10), pp.4246–4265. Available at: http://dx.doi.org/10.3390/molecules14104246.
Publication Details
Molecules
Copyright © 2009 Jampilek, T. et al.
This study was supported by the Polish Ministry of Science N405 178735, by the Ministry of Education of the Czech Republic MSM 6215712403 and by the Irish Department of Education and Science TSR Strand1-06/CR08 and by Sanofi-Aventis Pharma Slovakia.